P15: Analysis of Receptor’s Distribution in Entorhinal Cortex after Induction of Spreading Depression in Juvenile Rats
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p15: analysis of receptor’s distribution in entorhinal cortex after induction of spreading depression in juvenile rats
spreading depression (sd), discovered by leao in 1944, is a pathophysiological wave which propagates slowly in the brain (3 mm/min) and cause dramatic ionic and hemodynamic changes. sd appears to act through several mechanisms and receptors which have not completely understood. here, we studied the effect of inhibitory system in animal model of sd using immunohistochemistry technique. after imp...
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Introduction: Repetitive cortical spreading depression (CSD) can lead to cell death in immature brain tissue. Caspases are involved in neuronal cell death in several CSD-related neurological disorders. Yet, whether repetitive CSD itself can induce caspase activation in adult or juvenile tissue remains unknown. Inducing repetitive CSD in somatosensory cortices of juvenile and adult rats in vivo,...
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15 صفحه اولModulation of GABAergic transmission by muscarinic receptors in the entorhinal cortex of juvenile rats.
Whereas the entorhinal cortex (EC) receives profuse cholinergic innervations from the basal forebrain and activation of cholinergic receptors has been shown to modulate the activities of the principal neurons and promote the intrinsic oscillations in the EC, the effects of cholinergic receptor activation on GABAergic transmission in this brain region have not been determined. We examined the ef...
متن کاملModulation of GABAergic Transmission by Muscarinic Receptors in the Entorhinal 1 Cortex of Juvenile Rats
Modulation of GABAergic Transmission by Muscarinic Receptors in the Entorhinal 1 Cortex of Juvenile Rats 2 Zhaoyang Xiao, Pan-Yue Deng, Chuanxiu Yang and Saobo Lei 3 Department of Pharmacology, Physiology and Therapeutics, School of Medicine and 4 Health Sciences, University of North Dakota, Grand Forks, ND58203, USA 5 6 Running Head: Muscarinic Modulation of entorhinal GABA transmission 7 8 Co...
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عنوان ژورنال
دوره 2 شماره 4
صفحات 65- 65
تاریخ انتشار 2014-12
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